Synthesis of C -propargylic esters of N-protected amino acids and peptides

Bew, S.P. and Hiatt-Gipson, G.D. (2010) Synthesis of C -propargylic esters of N-protected amino acids and peptides. The Journal of Organic Chemistry, 75 (11). pp. 3897-3899.

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Abstract

Figure presented Recent years have seen a huge surge of interest in the application of alkyne-derived motifs for so-called "click" chemistry. Given the critical importance of amino acids in organic synthesis as well as their myriad of applications in "click" chemistry it is interesting to note that the synthesis of C-propargyl derived amino acid esters has not been particularly well served. We report a convenient, straightforward, and high-yielding synthesis of structurally diverse C-propargyl-derived N-protected amino acid esters. © 2010 American Chemical Society.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Related URLs:
Depositing User: Rachel Smith
Date Deposited: 07 Apr 2011 09:58
Last Modified: 21 Apr 2020 17:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/28343
DOI: 10.1021/jo100537q

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