Walmesley, Alice J, Zweiri, Jehad, Christmas, Stephen E and Watson, Alastair J M ORCID: https://orcid.org/0000-0003-3326-0426
(2007)
Rofecoxib has different effects on chemokine production in colorectal cancer cells and tumor immune splenocytes.
Journal of Immunotherapy, 30 (6).
pp. 614-623.
ISSN 1524-9557
Abstract
Cyclooxygenase-2 (COX-2) is overexpressed in colon tumors. Its main product is the immunosuppressive prostaglandin PGE2 that aids tumor immune escape. In this study, we analyzed mechanisms of action of the COX-2 inhibitor rofecoxib on the immune response to colorectal cancer in an animal model. The murine colorectal cancer cell line MC26, and splenocytes from BALB/c mice immune to irradiated MC26 cells, were incubated with rofecoxib or PGE2. In MC26 cells, 100 nM rofecoxib caused a complete abrogation of PGE2 production and inhibited cell proliferation. Splenocytes from tumor immune mice showed a 300% (P
Item Type: | Article |
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Uncontrolled Keywords: | animals,cell line, tumor,cell proliferation,chemokines,colorectal neoplasms,cyclooxygenase 2,cyclooxygenase 2 inhibitors,dinoprostone,female,gene expression,lactones,mice,mice, inbred balb c,monocytes,spleen,sulfones,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
Depositing User: | Rhiannon Harvey |
Date Deposited: | 01 Apr 2011 09:13 |
Last Modified: | 06 Feb 2023 16:30 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/27862 |
DOI: | 10.1097/CJI.0b013e31805ca039 |
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