Hypotheses on the etiology of antineutrophil cytoplasmic autoantibody associated vasculitis: The cause is hidden, but the result is known

de Lind van Wijngaarden, Robert A. F., van Rijn, Leendert, Hagen, E. Christiaan, Watts, Richard A, Gregorini, Gina, Tervaert, Jan Willem Cohen, Mahr, Alfred D., Niles, John L., de Heer, Emile, Bruijn, Jan A. and Bajema, Ingeborg M. (2008) Hypotheses on the etiology of antineutrophil cytoplasmic autoantibody associated vasculitis: The cause is hidden, but the result is known. Clinical Journal of the American Society of Nephrology, 3 (1). pp. 237-252. ISSN 1555-9041

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Abstract

The first description of what is now known as antineutrophil cytoplasmic autoantibody–associated necrotizing vasculitis appeared more than 140 yr ago. Since then, many aspects of the pathogenic pathway have been elucidated, indicating the involvement of antineutrophil cytoplasmic autoantibodies, but why antineutrophil cytoplasmic autoantibodies are produced in the first place remains unknown. Over the years, many hypotheses have emerged addressing the etiology of antineutrophil cytoplasmic antibody production, but no exclusive factor or set of factors can so far be held responsible. Herein is reviewed the most influential hypotheses regarding the causes of antineutrophil cytoplasmic antibody–associated vasculitis with the aim of placing in an epidemiologic background the different hypotheses that are centered on environmental and genetic influences.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Rhiannon Harvey
Date Deposited:	23 Mar 2011 12:57
Last Modified:	28 Mar 2025 03:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/27031
DOI:	10.2215/CJN.03550807

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