Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

Roy, Abhijeet Deb, Gruschow, Sabine, Cairns, Nickiwe and Goss, Rebecca J. M. (2010) Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs. Journal of the American Chemical Society, 132 (35). pp. 12243-12245.

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Abstract

Introduction of prnA, the halogenase gene from pyrrolnitrin biosynthesis, into Streptomyces coeruleorubidus resulted in efficient in situ chlorination of the uridyl peptide antibotic pacidamycin. The installed chlorine provided a selectably functionalizable handle enabling synthetic modification of the natural product using mild cross-coupling conditions in crude aqueous extracts of the culture broth.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Related URLs:
Depositing User: Rachel Smith
Date Deposited: 22 Mar 2011 15:57
Last Modified: 21 Apr 2020 16:59
URI: https://ueaeprints.uea.ac.uk/id/eprint/26909
DOI: 10.1021/ja1060406

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