Synthesis of tetra(trimethylammonio)phthalocyanato zinc tetraiodide, [ZnPc(NMe3)4]I4, and a spectrometric investigation of its interaction with calf thymus DNA

Duan, Wubiao, Wang, Zhenxin and Cook, Michael J. (2009) Synthesis of tetra(trimethylammonio)phthalocyanato zinc tetraiodide, [ZnPc(NMe3)4]I4, and a spectrometric investigation of its interaction with calf thymus DNA. Journal of Porphyrins and Phthalocyanines, 13 (12). pp. 1255-1261. ISSN 1088-4246

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Abstract

The phthalocyanine salt [ZnPc(NMe3)4]I4 was synthesized from 4-nitrophthalonitrile using a three-step procedure. The interaction of [ZnPc(NMe3)4]4+ with calf thymus DNA (CT DNA) has been investigated by UV-vis and fluorescence spectrometric methods. [ZnPc(NMe3)4]4+ exists in a non-monomeric form, proposed to be a dimer, in phosphate buffer solution (pH 6.82). Spectral changes show that in the presence of high concentrations of CT DNA added to the solution, [ZnPc(NMe3)4]4+ is bound in a monomeric state with evidence suggesting it is located in a DNA groove. At lower concentrations of DNA there is evidence of stacking of non-monomeric [ZnPc(NMe3)4]4+ onto the DNA. Two intrinsic binding constants for the interaction of [ZnPc(NMe3)4]4+ with CT DNA, 1.33 × 105 and 2.56 × 104 M-1 have been obtained. Electrostatic binding is shown to play an important role in the interaction of [ZnPc(NMe3)4]4+ with nucleic acids.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
Depositing User:	Rachel Smith
Date Deposited:	22 Mar 2011 13:29
Last Modified:	24 Sep 2024 09:21
URI:	https://ueaeprints.uea.ac.uk/id/eprint/26870
DOI:	10.1142/S1088424609001625

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