Cellular uptake of a fluorescent calix[4]arene derivative

Lalor, Ruth, Baillie-Johnson, Hugo, Redshaw, Carl, Matthews, Susan E. ORCID: https://orcid.org/0000-0001-8821-0851 and Mueller, Anja ORCID: https://orcid.org/0000-0003-0774-0434 (2008) Cellular uptake of a fluorescent calix[4]arene derivative. Journal of the American Chemical Society, 130 (10). pp. 2892-2893.

Full text not available from this repository. (Request a copy)


A rapid synthetic route to a nontoxic fluorescently labeled water-soluble calixarene has been developed. Investigation of the cellular uptake of the labeled calixarene, via confocal microscopy, through coincubation with uptake inhibitors demonstrates that uptake is not through the common clathrin coated pits or caveolae (lipid raft) endocytic pathways and that the calixarene derivative localizes within the cytoplasm and does not enter the nucleus. The study demonstrates the power of fluorescent labeling for investigation of interactions between calixarenes and biological systems and the potential for calixarene based intracellular imaging agents.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 16 Mar 2011 16:19
Last Modified: 12 Jan 2023 16:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/26430
DOI: 10.1021/ja0782596

Actions (login required)

View Item View Item