Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol

Karki, Shyam, Friščić, Tomislav, Fabian, Laszlo, Laity, Peter R., Day, Graeme M. and Jones, William (2009) Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol. Advanced Materials, 21 (38-39). pp. 3905-3909. ISSN 0935-9648

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Abstract

Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: Rachel Smith
Date Deposited: 15 Mar 2011 15:53
Last Modified: 31 Oct 2019 13:37
URI: https://ueaeprints.uea.ac.uk/id/eprint/26263
DOI: 10.1002/adma.200900533

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