Cell-mediated immunity of patients who have had basal cell carcinoma

Czarnecki, D., Mar, A. and Kulinskaya, E. (1996) Cell-mediated immunity of patients who have had basal cell carcinoma. Acta Dermato-Venereologica, 76 (1). pp. 28-30. ISSN 1651-2057

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The cell-mediated immunity of patients who had basal cell carcinomas (BCCs) removed was studied by measuring cuntaneous delayed hypersensitivity reactions to recall antigens (Multitest CMI, Pasteur-Merieux), and by measuring lymphocyte counts and subsets. One group of patients had multiple BCCs (3 or more) removed and were considered to have a high risk of new BCC formation. The other group consisted of patients who had one BCC and had not developed another within 5 years; these were considered to have a low risk of new BCC formation. The low-risk patients had significantly larger cutaneous reactions to recall antigens (p < 0.05) and significantly fewer were anergic (p < 0.01). There was a correlation between smaller cutaneous reactions and increasing numbers of BCCs (p < 0.05). There was no significant difference between the groups in lymphocyte counts or subsets, but the low-risk patients had a significantly higher CD4:CD8 ratio (p < 0.05) than the high-risk group. The Multitest CMI test can be used to determine which patients are at risk of developing many BCCs.

Item Type: Article
Faculty \ School: Faculty of Science > School of Computing Sciences
Depositing User: Vishal Gautam
Date Deposited: 08 Mar 2011 11:39
Last Modified: 24 Oct 2022 04:06
URI: https://ueaeprints.uea.ac.uk/id/eprint/23892
DOI: 10.2340/00015555762830

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