Synthetic Macrocyclic Peptidomimetics as Tunable pH Probes for the Fluorescence Imaging of Acidic Organelles in Live Cells

Galindo, Francisco, Burguete, M. Isabel, Vigara, Laura, Luis, Santiago V., Kabir, Nurul, Gavrilovic, Jelena and Russell, David A. (2005) Synthetic Macrocyclic Peptidomimetics as Tunable pH Probes for the Fluorescence Imaging of Acidic Organelles in Live Cells. Angewandte Chemie-International Edition, 44 (40). pp. 6504-6508. ISSN 1433-7851

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Abstract

Acid test: Macrocyclic compounds that comprise a 9,10-anthracene subunit linked by a C2-symmetric peptidomimetic chain (see formula) are useful as fluorescent probes in a pH range of biomedical interest. Changes in the size of the macrocycle (n=3,4,6,8) produce a shift in the pKa values. Experiments with live mouse macrophage cells show the selective localization of the probe in the acidic organelles (see differential interference contrast image).

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science > School of Chemistry
Related URLs:
Depositing User: Rachel Smith
Date Deposited: 21 Jan 2011 16:35
Last Modified: 21 Apr 2020 20:02
URI: https://ueaeprints.uea.ac.uk/id/eprint/19744
DOI: 10.1002/anie.200501920

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