Galindo, Francisco, Burguete, M. Isabel, Vigara, Laura, Luis, Santiago V., Kabir, Nurul, Gavrilovic, Jelena ORCID: https://orcid.org/0000-0002-5312-1784 and Russell, David A.
(2005)
Synthetic macrocyclic peptidomimetics as tunable pH probes for the fluorescence imaging of acidic organelles in live cells.
Angewandte Chemie-International Edition, 44 (40).
pp. 6504-6508.
ISSN 1433-7851
Abstract
Acid test: Macrocyclic compounds that comprise a 9,10-anthracene subunit linked by a C2-symmetric peptidomimetic chain (see formula) are useful as fluorescent probes in a pH range of biomedical interest. Changes in the size of the macrocycle (n=3,4,6,8) produce a shift in the pKa values. Experiments with live mouse macrophage cells show the selective localization of the probe in the acidic organelles (see differential interference contrast image).
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Biological Sciences Faculty of Science > School of Chemistry |
UEA Research Groups: | Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017) Faculty of Science > Research Groups > Cells and Tissues |
Depositing User: | Rachel Smith |
Date Deposited: | 21 Jan 2011 16:35 |
Last Modified: | 21 Apr 2023 22:31 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/19744 |
DOI: | 10.1002/anie.200501920 |
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