Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

Burguete, M. Isabel, Galindo, Francisco, Gavara, Raquel, Luis, Santiago V., Moreno, Miguel, Thomas, Paul and Russell, David A. (2009) Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells. Photochemical & Photobiological Sciences, 8 (1). pp. 37-44. ISSN 1474-905X

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Abstract

Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry
Depositing User:	Rachel Smith
Date Deposited:	24 Jan 2011 11:42
Last Modified:	24 Oct 2022 00:12
URI:	https://ueaeprints.uea.ac.uk/id/eprint/19723
DOI:	10.1039/b810921d

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