Regulation of jejunal glucose transporter expression by forskolin

Williams, M. R. and Sharp, P. (2002) Regulation of jejunal glucose transporter expression by forskolin. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1559 (2). pp. 179-185. ISSN 0005-2736

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Abstract

We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. No change in transporter expression was noted in upper villus cells. Likewise, cyclic AMP levels were raised in mid and lower but not upper villus cells. The implications of these data for glucose transport are discussed.

Item Type: Article
Faculty \ School: Faculty of Science
Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: Vishal Gautam
Date Deposited: 01 Feb 2002
Last Modified: 24 Jul 2019 17:28
URI: https://ueaeprints.uea.ac.uk/id/eprint/18055
DOI: 10.1016/S0005-2736(01)00449-7

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