Rotavirus surveillance in Europe 2005-2008: Web-enabled reporting and real-time analysis of genotyping and epidemiological data

Iturriza-Gomara, M, Dallman, T, Banyai, K, Bottiger, B, Buesa, J, Diedrich, S, Fiore, L, Johansen, K, Korsun, N, Kroneman, A, Lappalainen, M, Laszlo, B, Maunula, L, Matthinjnssens, J, Midgley, S, Mladenova, Z, Poljsak-Prijatelj, M, Pothier, P, Ruggeri, FM, Sanchez-Fauquier, A, Schreier, E, Steyer, A, Sidaraviciute, I, Tran, AN, Usonis, V, Van Ranst, M, de Rougemont, A and Gray, JJ (2009) Rotavirus surveillance in Europe 2005-2008: Web-enabled reporting and real-time analysis of genotyping and epidemiological data. Journal of Infectious Diseases, 200 (Suppl 1). S215-221. ISSN 0022-1899

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Abstract

Background: The first European rotavirus surveillance network, EuroRotaNet, comprising 16 laboratories in 15 European countries, has been established. Methods: Fecal samples from gastroenteritis cases positive for group A rotavirus antigen were collected from multiple European countries from 2005 to mid-2008 and were subjected to G and P genotyping. Epidemiological data collected included age, sex, geographical location, setting, dates of onset and sample collection, and clinical symptoms. Results: A total of 8879 rotavirus-positive samples were characterized: 2129 cases were from the 2005–2006 season, 4030 from the 2006–2007 season, and 2720 from the ongoing 2007–2008 season. A total of 30 different G and P type combinations of strains circulated in the region from 2005 through 2008. Of these strains, 90% had genotypes commonly associated with human infections—G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8]—and 1.37% represented potential zoonotic introductions. G1P[8] remained the most prevalent genotype in Europe as a whole, but the incidence of infection with G1P[8] rotavirus strains was <50% overall, and all 3 seasons were characterized by a significant diversity of cocirculating strains. The peak incidence of rotavirus infection occurred from January through May, and 81% of case patients were aged <2.5 years. Conclusions: Data gathered through EuroRotaNet will provide valuable background information on the rotavirus strain diversity in Europe before the introduction of rotavirus vaccines, and the network will provide a robust method for surveillance during vaccine implementation.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:13
Last Modified:	14 Jul 2023 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/15631
DOI:	10.1086/605049

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