Home-based exercise training modulates pro-oxidant substrates in patients with chronic heart failure

Niebauer, Josef, Clark, Andrew L., Webb-Peploe, Katharine M., Boger, Rainer and Coats, Andrew J. S. (2005) Home-based exercise training modulates pro-oxidant substrates in patients with chronic heart failure. European Heart Journal, 7 (2). pp. 183-188. ISSN 1522-9645

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Background: In chronic heart failure, oxidative stress is thought to lead to endothelial dysfunction. In this study, we assessed the effect of home-based exercise training on variables of the NO and purine pathways. Methods and results: Eighteen patients and nine controls were randomly assigned in cross-over design to 8 weeks of exercise training (5 days/week, submaximal bicycle ergometer training, 30 min/day; calisthenics 9 min/day) and 8 weeks of sedentary lifestyle. Hypoxanthine, xanthine, l-arginine, asymmetric dimethylarginine (ADMA), symmetric DMA (SDMA) and nitrite were measured. In patients, exercise training led to an increase in peak VO2 (p<0.003). At baseline hypoxanthine—a pro-oxidant substrate and marker of hypoxia—was higher in patients than in controls (24.6±4.3 vs. 11.9±4.2 μmol/l; p<0.05). After training there was a reduction in hypoxanthine (p<0.01). Nitrite levels were lower in patients (416±31 μmol/l) than in healthy controls (583±35 μmol/l, p<0.001). Although nitrite levels were highest after exercise, the changes did not reach statistical significance (p=n.s.). l-Arginine, ADMA, and SDMA levels were not different between groups and were not altered by exercise training. Conclusions: Chronic heart failure is associated with increased levels of hypoxanthine and decreased levels of nitrite. This imbalance can be beneficially modulated by chronic home-based exercise training.

Item Type: Article
Faculty \ School:
Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:13
Last Modified: 17 Jan 2024 01:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/15408
DOI: 10.1016/j.ejheart.2004.06.001

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