Serum prohepcidin concentration:no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women

Roe, Mark A., Spinks, Caroline, Heath, Anne-Louise M., Harvey, Linda J., Foxall, Rob, Wimperis, Jennie, Wolf, Christian and Fairweather-Tait, Susan J. (2007) Serum prohepcidin concentration:no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women. British Journal of Nutrition, 97 (3). pp. 544-549. ISSN 1475-2662

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Abstract

Hepcidin plays a major role in iron homeostasis, but understanding its role has been hampered by the absence of analytical methods for quantification in blood. A commercial ELISA has been developed for serum prohepcidin, a hepcidin precursor, and there is interest in its potential use in the clinical and research arena. We investigated the association between serum prohepcidin concentration and iron absorption in healthy men, and its relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients, and pregnant women. Iron absorption was determined in thirty healthy men (fifteen wild-type, fifteen C282Y heterozygote) using the stable isotope red cell incorporation technique. Iron status was measured in 138 healthy men (ninety-one wild-type, forty-seven C282Y heterozygote), six hereditary haemochromatosis patients, and thirteen pregnant women. Mean serum prohepcidin concentrations were 214 (SD 118) ng/ml [208 (SD 122) ng/ml in wild-type and 225 (SD 109) ng/ml in C282Y heterozygotes] in healthy men, 177 (SD 36) ng/ml in haemochromatosis patients, and 159 (SD 59) ng/ml in pregnant women. There was no relationship between serum prohepcidin concentration and serum ferritin in any subject groups, nor was it associated with efficiency of iron absorption. Serum prohepcidin is not a useful biomarker for clinical or research purposes.

Item Type: Article
Uncontrolled Keywords: adolescent,adult,antimicrobial cationic peptides,biological markers,dietary supplements,female,ferritins,ferrous compounds,genotype,hematinics,hemochromatosis,hepcidins,heterozygote,histocompatibility antigens class i,humans,intestinal absorption,iron, dietary,male,membrane proteins,mutation,phlebotomy,pregnancy,prenatal care,protein precursors,single-blind method
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
Depositing User: EPrints Services
Date Deposited: 01 Oct 2010 13:38
Last Modified: 21 Apr 2020 19:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/1537
DOI: 10.1017/S0007114507336829

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