Beta blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure)

van Veldhuisen, DJ, Cohen-Solal, A, Bohm, M, Anker, SD, Babalis, D, Roughton, M, Coats, AJ, Poole-Wilson, PA, Flather, MD and , SENIORS Investigators (2009) Beta blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure). Journal of the American College of Cardiology, 53 (23). pp. 2150-2158. ISSN 0735-1097

Full text not available from this repository. (Request a copy)

Abstract

Background: Beta-blockers are established drugs in patients with HF and impaired EF, but their value in preserved EF is unclear. Methods: We studied 2,111 patients; 1,359 (64%) had impaired (=35%) EF (mean 28.7%) and 752 (36%) had preserved (>35%) EF (mean 49.2%). The effect of nebivolol was investigated in these 2 groups, and it was compared to explore the interaction of EF with outcome. Follow-up was 21 months; the primary end point was all-cause mortality or cardiovascular hospitalizations. Results: Patients with preserved EF were more often women (49.9% vs. 29.8%) and had less advanced HF, more hypertension, and fewer prior myocardial infarctions (all p < 0.001). During follow-up, the primary end point occurred in 465 patients (34.2%) with impaired EF and in 235 patients (31.2%) with preserved EF. The effect of nebivolol on the primary end point (hazard ratio [HR] of nebivolol vs. placebo) was 0.86 (95% confidence interval: 0.72 to 1.04) in patients with impaired EF and 0.81 (95% confidence interval: 0.63 to 1.04) in preserved EF (p = 0.720 for subgroup interaction). Effects on all secondary end points were similar between groups (HR for all-cause mortality 0.84 and 0.91, respectively), and no p value for interaction was

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:13
Last Modified: 21 Apr 2020 17:28
URI: https://ueaeprints.uea.ac.uk/id/eprint/15359
DOI: 10.1016/j.jacc.2009.02.046

Actions (login required)

View Item View Item