Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

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Venelinov, Tony I, Beattie, John H, Dainty, Jack R ORCID: https://orcid.org/0000-0002-0056-1233, Hollands, Wendy J, Fairweather-Tait, Susan J ORCID: https://orcid.org/0000-0002-1413-5569 and Harvey, Linda J (2007) Stable isotope pilot study of exchangeable copper kinetics in human blood plasma. Journal of Trace Elements in Medicine and Biology, 21 (2). pp. 138-140. ISSN 0946-672X

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Abstract

To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3mg oral doses of the stable isotope (65)Cu and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame.

Item Type:	Article
Uncontrolled Keywords:	albumins,ceruloplasmin,copper radioisotopes,humans,pilot projects,plasma
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	http://dx.doi.org/10.1016/j.jtemb.2007.0...
Depositing User:	EPrints Services
Date Deposited:	01 Oct 2010 13:38
Last Modified:	24 Oct 2022 01:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/1528
DOI:	10.1016/j.jtemb.2007.01.001

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