In vitro effect of DNA topoisomerase inhibitors on Candida albicans

Kwok, Shing C., Schelenz, Silke, Wang, Xia and Steverding, Dietmar (2010) In vitro effect of DNA topoisomerase inhibitors on Candida albicans. Medical Mycology, 48 (3). pp. 155-160. ISSN 1369-3786

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Abstract

In this paper we report the results of the study of the in vitro effect of eight anticancer DNA topoisomerase inhibitors on the growth of Aspergillus fumigatus, A. niger, Candida glabrata and Cryptococcus neoformans. Only one compound, idarubicin, displayed promising antifungal activity against A. niger, C. glabrata and C. neoformans with MIC(50) values varying between 3.6 and 14.2 μM (1.8-7.1 μg/ml). Three other compounds, aclarubicin, doxorubicin and mitoxantrone, showed some antifungal activity against C. glabrata and C. neoformans with MIC(50) values in the mid micromolar range. The data of this study indicate that selected DNA topoisomerase inhibitors are a promising class of compounds for the development of new antifungal agents.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:13
Last Modified:	23 Oct 2022 01:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/15092
DOI:	10.3109/13693780903114934

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