A model protocol evaluating the introduction of genetic assessment for women with a family history of breast cancer

Gray, Jonathon, Brain, Kate, Norman, Paul, Anglim, Cathy, France, Liz, Barton, Garry, Branston, Lucy, Parsons, Evelyn, Clarke, Angus, Sampson, Julian, Roberts, Elizabeth, Newcombe, Robert, Cohen, David and Rogers, Cerilan (2000) A model protocol evaluating the introduction of genetic assessment for women with a family history of breast cancer. Journal of Medical Genetics, 37 (3). pp. 192-196. ISSN 1468-6244

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Abstract

Randomised controlled trials allow comparisons to be made between different models of service delivery, but have not been used in the field of clinical genetics. With the advent of clinical governance, the evidence provided by such trials will be increasingly important in informing and shaping clinical genetics practice. The TRACE project (Trial of genetic assessment in breast cancer) is a randomised controlled trial of genetic assessment for women who are at increased risk of breast cancer because of their family history. The absence of cancer genetics service provision in Wales before this study gave a window of opportunity in which this important trial could be conducted. The present paper describes how TRACE will provide crucial evidence regarding the psychosocial as well as resource implications of adding individualised genetic assessment, genetic counselling, and (where appropriate) gene testing to typical advice and surveillance from a hospital breast clinic. In addition, it is anticipated that TRACE will represent a model for future trials of service delivery in the increasing number of complex genetic disorders where evidence on the economic implications of screening and management is currently limited.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Health Economics
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:12
Last Modified:	15 Dec 2022 01:54
URI:	https://ueaeprints.uea.ac.uk/id/eprint/14424
DOI:	10.1136/jmg.37.3.192

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