Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men

Roe, Mark A, Collings, Rachel, Dainty, Jack R, Swinkels, Dorine W and Fairweather-Tait, Susan J (2009) Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men. American Journal of Clinical Nutrition, 89 (4). pp. 1088-1091. ISSN 0002-9165

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Abstract

Background: Iron absorption is proposed to be regulated by circulating hepcidin, but, to date, little data are available to evaluate this relation in humans. Objective: Stored samples from a human iron absorption study were used to test the hypothesis that differences in plasma hepcidin explain interindividual variation in iron absorption. Design: Hepcidin-25 concentrations were measured in fasting samples from men aged ≥40 y (n = 33) recruited to a study investigating the relation between the HFE genotype, iron absorption, and iron status. Results: Log iron absorption was negatively correlated with serum ferritin (r = −0.59, P < 0.001) and with plasma hepcidin (r = −0.55, P < 0.001) but was unaffected by genotype. There was a positive correlation (r = 0.82, P < 0.001) between hepcidin (mean: 2.3; range: 0.1–7.8 nmol/L) and ferritin (mean: 70; range: 9–208 μg/L). Multiple linear regression models showed that plasma hepcidin in isolation significantly predicted 36% of the interindividual variation in iron absorption. Conclusions: Plasma hepcidin and serum ferritin concentrations are highly correlated, and, in the normal range of plasma hepcidin values, 36% of interindividual differences in iron absorption are explained by differences in circulating plasma hepcidin.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:11
Last Modified: 28 Oct 2019 13:42
URI: https://ueaeprints.uea.ac.uk/id/eprint/14103
DOI: 10.3945/ajcn.2008.27297

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