Antitrypanosomal activities of proteasome inhibitors

Nkemngu-Njinkeng, Joseph, Rosenkranz, Vera, Wink, Michael and Steverding, Dietmar (2002) Antitrypanosomal activities of proteasome inhibitors. Antimicrobial Agents and Chemotherapy, 46 (6). pp. 2038-2040. ISSN 0066-4804

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Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:10
Last Modified: 24 Oct 2022 03:23
DOI: 10.1128/AAC.46.6.2038-2040.2002

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