A family based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects

Lange, Christoph, van Steen, Kristel, Andrew, Toby, Lyon, Helen, DeMeo, Dawn L., Raby, Benjamin, Murphy, Amy, Silverman, Edwin K., MacGregor, Alex, Weiss, Scott T. and Laird, Nan M. (2004) A family based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Statistical Applications in Genetics and Molecular Biology, 3 (1). pp. 1-17. ISSN 1544-6115

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Abstract

We propose a family-based association test, FBAT-PC, for studies with quantitative traits that are measured repeatedly. The traits may be influenced by partially or completely unknown factors that may vary for each measurement. Using generalized principal component analysis, FBAT-PC amplifies the genetic effects of each measurement by constructing an overall phenotype with maximal heritability. Analytically, and in the simulation studies, we compare FBAT-PC with standard methodology and assess both the heritability of the overall phenotype and the power of FBAT-PC. Compared to univariate analysis, FBAT-PC achieves power gains of up to 200%. Applications of FBAT-PC to an osteoporosis study and to an asthma study show the practical relevance of FBAT-PC. FBAT-PC has been implemented in the software package PBAT and is freely available at http://www.biostat.harvard.edu/~clange/default.htm.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:10
Last Modified:	28 Mar 2025 04:25
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13089
DOI:	10.2202/1544-6115.1067

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