MicroRNAs and the Hallmarks of Cancer

Dalmay, T. ORCID: https://orcid.org/0000-0003-1492-5429 and Edwards, D.R. ORCID: https://orcid.org/0000-0002-3292-2064 (2006) MicroRNAs and the Hallmarks of Cancer. Oncogene, 25. pp. 6170-6175. ISSN 1476-5594

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Abstract

It has become clear that particular microRNAs (miRNAs) function either as tumour suppressors or oncogenes, whose loss or overexpression, respectively, has diagnostic and prognostic significance. In several cases, miRNAs have been shown to affect target genes that are involved in the control of cell proliferation and apoptosis. However, malignant tumours display additional traits beyond the acquisition of enhanced growth potential and decreased cell death. Malignant disease is associated with altered tumour–host interactions leading to sustained angiogenesis and the ability to invade and metastasize. It is possible that miRNAs may act as master regulators of these aspects of tumour biology. Bioinformatic analysis of putative miRNA binding sites has indicated several novel potential gene targets of cancer-associated miRNAs that function in aspects of cell adhesion, neovascularization and tissue invasion. Among others, we speculate that miRNAs may find new roles in the regulation of E-cadherin, integrin αvβ3, hypoxia-inducible factor-1α, syndecan-1, lysyl oxidase, adamalysin metalloproteinase-17, tissue inhibitors of metalloproteinase-3, c-Met and CXCR-4 that underpin the tissue architectural changes associated with malignancy.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Biological Sciences
Depositing User:	EPrints Services
Date Deposited:	01 Oct 2010 13:38
Last Modified:	09 Feb 2023 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/1307
DOI:	10.1038/sj.onc.1209911

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