African swine fever virus infection disrupts centrosome assembly and function

Jouvenet, Nolween and Wileman, Thomas (2005) African swine fever virus infection disrupts centrosome assembly and function. Journal of General Virology, 86 (3). pp. 589-594. ISSN 1465-2099

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Abstract

African swine fever virus (ASFV) is a large, enveloped DNA virus that assembles in perinuclear sites located close to the centrosome. It is reported here that the microtubule network becomes disorganized soon after the onset of viral DNA replication and formation of assembly sites. ASFV infection resulted in loss of γ-tubulin and pericentrin at the centrosome; this was due to protein relocalization, but not degradation. ASFV infection also inhibited the ability of the centrosome to nucleate microtubules. The reorganization of microtubules seen in ASFV-infected cells may therefore be mediated by γ-tubulin and pericentrin redistribution, and consequent disruption of centrosome assembly and function.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Medicine (former - to 2013) Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:10
Last Modified:	14 Aug 2023 09:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/12999
DOI:	10.1099/vir.0.80623-0

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