The significance of transferrin receptor variation in Trypanosoma brucei

Steverding, D (2003) The significance of transferrin receptor variation in Trypanosoma brucei. Trends in Parasitology, 19 (3). pp. 125-127. ISSN 1471-4922

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The transferrin receptor of Trypanosoma brucei is encoded by genes located in different expression sites. The various expression sites encode slightly different transferrin receptors, which differ substantially in their affinity for transferrin of different host species. It was proposed that T. brucei has developed multiple expression sites encoding different transferrin receptors not only to cope with the diversity of mammalian transferrins, but also to ensure sufficient iron uptake in the presence of anti-transferrin receptor antibodies. This article shows that calculations based on K(d) values argue against the first part of the hypothesis, but might support the second part.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:08
Last Modified: 24 Oct 2022 03:03

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