Hematopoietic stem cell aging and leukemia transformation

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Colom Díaz, Patricia A., Mistry, Jayna J. and Trowbridge, Jennifer J. (2023) Hematopoietic stem cell aging and leukemia transformation. Blood, 142 (6). pp. 533-542. ISSN 0006-4971

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Abstract

With aging, hematopoietic stem cells (HSCs) have an impaired ability to regenerate, differentiate, and produce an entire repertoire of mature blood and immune cells. Owing to dysfunctional hematopoiesis, the incidence of hematologic malignancies increases among elderly individuals. Here, we provide an update on HSC-intrinsic and -extrinsic factors and processes that were recently discovered to contribute to the functional decline of HSCs during aging. In addition, we discuss the targets and timing of intervention approaches to maintain HSC function during aging and the extent to which these same targets may prevent or delay transformation to hematologic malignancies.

Item Type: Article
Additional Information: Publisher Copyright: © 2023 The American Society of Hematology
Uncontrolled Keywords: biochemistry,immunology,hematology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1303
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Depositing User: LivePure Connector
Date Deposited: 11 Nov 2026 10:25
Last Modified: 11 Nov 2026 10:25
URI: https://ueaeprints.uea.ac.uk/id/eprint/105067
DOI: 10.1182/blood.2022017933

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