Nutrition for the Ageing Brain: Towards Integration of Dietary and Lifestyle Strategies

Cvejić, Jelena Helene, Matusheski, Nathan, Bowman, Gene L., Cirulli, Francesca, Contreras Rodriguez, Oren, Chrousos, George, Dye, Louise, Dickson, Suzanne L., Godos, Justyna, Hepsomali, Piril, Korosi, Aniko, Manach, Claudine, McEvoy, Claire, Minihane, Anne-Marie ORCID: https://orcid.org/0000-0001-9042-4226, Musillo, Chiara, Santos, Claudia Nunes, Panza, Francesco, Proitsi, Petra, Rudka, Tomasz, Teeling, Jessica, Tonti, Maria, Vanden Berghe, Wim, Vanhatalo, Anni, Vauzour, David ORCID: https://orcid.org/0000-0001-5952-8756, Vermeiren, Yannick, Verstraeten, Laure, Wojdała, Anna Lidia and Thuret, Sandrine (2026) Nutrition for the Ageing Brain: Towards Integration of Dietary and Lifestyle Strategies. Neuroscience Applied. ISSN 2772-4085

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Abstract

The global rise in life expectancy has brought cognitive ageing and brain health to the forefront of public health priorities. Advances in neuroscience and systems biology have redefined the brain as a dynamic, multisystem organ, deeply interconnected with peripheral physiology, immune function, and metabolism. This integrative perspective highlights the substantial influence of lifestyle factors including nutrition, physical activity, sleep, and psychosocial stress on neural plasticity, cognitive performance, and emotional resilience in ageing. The 2025 ILSI Symposium on the Ageing Brain convened international experts to explore the interplay between diet, lifestyle, and cognitive health. Key themes included the role of diet quality and composition in modulating neuroinflammatory pathways, neurogenesis, and metabolic regulation. Evidence supports Mediterranean-style dietary patterns, certain bioactive compounds, and nutraceuticals as promising strategies to enhance neuroprotection and resilience against age-related cognitive decline and neurodegeneration. Multi-omics and biomarker research are further elucidating the molecular mechanisms linking nutrition to brain ageing, while fluid biomarkers are enabling earlier detection and precision prevention trials. The proceedings highlight the importance of early-life nutrition, the influence of psychosocial and socioeconomic factors, and the intersection of sex differences, menopause, and undernutrition in shaping cognitive trajectories. Emerging evidence on oral health and the oral microbiome as contributors to neuroinflammation and cognitive decline expands the scope of modifiable risk factors. Despite considerable progress, translating mechanistic insights into effective, population-level interventions remains a challenge. The symposium emphasizes the need for multidisciplinary collaboration, large-scale longitudinal studies, and the integration of advanced biomarkers to make evidence-based recommendations. Ultimately, promoting brain health across the lifespan will require bridging scientific discovery with practical application, ensuring that longer lives are accompanied by preserved cognitive function, emotional well-being and quality of life.

Item Type:	Article
Uncontrolled Keywords:	nutrition,cognitive ageing,neuroinflammation,lifestyle,oral health,microbiome,das to be completed,2026 ,/dt/atira/pure/keyword/DAStatement/das_to_be_completed
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Related URLs:	https://linkinghub.elsevier.com/retrieve...
Depositing User:	LivePure Connector
Date Deposited:	10 Nov 2026 10:05
Last Modified:	10 Nov 2026 10:05
URI:	https://ueaeprints.uea.ac.uk/id/eprint/105033
DOI:	10.1016/j.nsa.2026.107033

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