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Alageel, Sarah, Hibberd, Jane and Deane, Katherine H. O. 
ORCID: https://orcid.org/0000-0002-0805-2708
(2026)
Pilot randomized controlled trial of the ReFresh online fatigue management programme for people with Parkinson’s disease.
Neurodegenerative Disease Management.
ISSN 1758-2024
Abstract
Aims: Fatigue is one of the most disabling symptoms experienced by people with Parkinson’s disease, yet few evidence-based non-pharmacological interventions are available. This study evaluated the feasibility, acceptability, and exploratory clinical signals of the Rebalancing Fatigue and Enhancing Self-Help (ReFresh) online fatigue management programme for people with Parkinson’s disease. Patients and methods: A pilot randomized controlled trial with a wait-list control group was conducted. Participants with Parkinson’s disease experiencing fatigue were randomized to either the six-week ReFresh online programme or a wait-list control. Feasibility outcomes included recruitment, retention, adherence, and participant engagement. Secondary outcomes included fatigue severity, fatigue self-efficacy, sleep quality, mood, and occupational performance. Results: A total of 118 participants were randomized. Recruitment targets were achieved; however, retention and adherence were modest. Participants who completed the programme reported improvements in fatigue self-efficacy and perceived ability to manage fatigue, while changes in fatigue severity were smaller. Qualitative feedback indicated that participants valued the flexibility and accessibility of the online format. Conclusions: The ReFresh programme demonstrated feasibility and acceptability as a digitally delivered fatigue management intervention for people with Parkinson’s disease. Future research should explore strategies to improve engagement and evaluate the programme in a fully powered randomized controlled trial.
| Item Type: | Article |
|---|---|
| Additional Information: | Data availability statement: De-identified participant data, statistical analysis scripts, the TIDieR checklist and the logic model will be deposited on the Open Science Framework upon publication. Prior to publication, reasonable requests can be directed to the corresponding author. |
| Uncontrolled Keywords: | parkinson’s disease,pilot randomized controlled trial,fatigue management,fatigue self-efficacy,feasibility study,non-pharmacological intervention,online fatigue intervention,self-management programme,clinical neurology ,/dk/atira/pure/subjectarea/asjc/2700/2728 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Arts and Humanities > Research Groups > Gender and Its Intersections Faculty of Medicine and Health Sciences > Research Centres > Institute for Volunteering Research Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Centres > Mental Health and Social Care (fka Lifespan Health) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Nov 2026 15:08 |
| Last Modified: | 05 Nov 2026 15:08 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/104983 |
| DOI: | 10.1080/17582024.2026.2647107 |
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