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Whelan, F. J. and Hall, L. J. 
ORCID: https://orcid.org/0000-0001-8938-5709
(2026)
An ode to the 16S rRNA gene: its history, importance, caveats and future in microbiome research.
Microbial Genomics, 12 (8).
ISSN 2057-5858
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Abstract
The 16S rRNA gene has-and continues to-play an important role in microbiology. It’s universality across prokaryotes and variation across species has allowed the sequencing of its hypervariable regions to be used to distinguish taxa within complex mixed bacterial communities. Although 16S rRNA gene sequencing has transformed our understanding of microbial communities, its use comes with important caveats and considerations, especially in light of the availability of whole-genome metagenomic sequencing. Within, we discuss the 16S rRNA gene and its important role in microbiome research, in the past, present, and future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 16s rrna gene sequencing,microbiome research,epidemiology,microbiology,molecular biology,genetics,das to be completed,2026 ,/dk/atira/pure/subjectarea/asjc/2700/2713 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 29 Oct 2026 13:47 |
| Last Modified: | 29 Oct 2026 13:47 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/104912 |
| DOI: | 10.1099/mgen.0.001823 |
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