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Thompson, Sophie, Venables, Zoe C. 
ORCID: https://orcid.org/0000-0002-9929-2693, Levell, Nick J. ORCID: https://orcid.org/0000-0003-3393-8305, Stiller, Charles and McCabe, Martin G.
(2026)
Recent trends in childhood, teenage and young adult cancer incidence in England (2001–2020).
European Journal of Cancer, 248.
ISSN 0959-8049
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Abstract
Introduction: Cancer remains a leading cause of death among children, teenagers and young adults (CTYAs) in England with a distinct incidence profile compared to older adults. We examined trends in cancer incidence among individuals aged ' 25 years in England from 2001 to 2020 using openly available National Disease Registration Service (NDRS) data. Materials and Methods: All malignancies (ICD-10 C00–C97) diagnosed between 2001 and 2020 were extracted from published NDRS official registration statistics. Analyses were stratified into children (0–14 years) and TYAs (15–24 years), with subanalyses by gender. Joinpoint regression analysis (SEER v5.4.0) was used to calculate annual percentage change (APC) in age-specific incidence and identify trend changes. 2020 data were excluded from trend analyses due to COVID-19 related disruption. Instant rate ratios (IRRs) directly compared rates in 2020–2019. Results: Between 2001 and 2020, cancer incidence was 147 and 273 per million person-years in children and TYAs, respectively. In children, lymphoid leukaemia and brain/CNS tumours accounted for 46% of diagnoses. Among TYAs, Hodgkin lymphoma (15%) and malignant melanoma (9%) were most common, and 24% of male cancers were testicular. TYA colorectal cancer incidence increased until 2015, then declined from 2015 to 19 (APC −37.59%, p ' 0.001). Thyroid cancer incidence rose throughout the study period (APC +5.49%, p ' 0.001), while cervical cancer incidence declined from 2015 to 19 (APC −21.9%, p = 0.03). Cervical cancer incidence fell the most from 2019 to 2020 (IRR 0.38, p = 0.09). Conclusions: Overall cancer incidence in CTYAs remains low. Trends in colorectal and cervical cancer may reflect appendiceal carcinoid reclassification, HPV vaccination, and COVID-19 related disruption to diagnostic and screening services.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cancer incidence,childhood cancer,covid-19,england,epidemiology,joinpoint regression,paediatric and adolescent oncology,teenagers and young adults,oncology,cancer research,sdg 3 - good health and well-being,das to be completed,2026 ,/dk/atira/pure/subjectarea/asjc/2700/2730 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Public Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 15 Oct 2026 12:55 |
| Last Modified: | 18 Oct 2026 23:11 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/104786 |
| DOI: | 10.1016/j.ejca.2026.117448 |
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