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Ulman, Mateusz, Boczar, Krzysztof, Karkowski, Grzegorz, Holcman, Katarzyna, Dębski, Maciej 
ORCID: https://orcid.org/0000-0002-3669-3916, Kostkiewicz, Magdalena, Lelakowski, Jacek and Ząbek, Andrzej
(2026)
Survival of patients with cardiac implantable electronic device infections after transvenous lead extraction.
Kardiologia Polska, 84 (2).
pp. 231-237.
ISSN 0022-9032
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Abstract
Background: Cardiac implantable electronic device (CIED) infections, particularly CIED-associated infective endocarditis (CIED-associated IE), are associated with a high 1-year mortality rate of 14%–35%, reduced quality of life, and increased burden on the healthcare system. Aims: In this prospective, single-center, high-volume referral study, we aimed to analyze and compare 3 groups of patients who underwent transvenous lead extraction (TLE): patients with CIED-associated IE, patients with pocket infection (PI), and both. Methods: This study included all consecutive patients with CIEDs who underwent TLE due to device-related infection at a tertiary referral hospital between 2011 and 2023. Patients were divided into 3 groups (CIED-associated IE, PI, and both indications) based on the modified Duke criteria. Results: A total of 253 consecutive patients underwent TLE. Of these, 135 (53%) were treated for PI, 90 (36%) for CIED-associated IE, and 28 (11%) for both indications. Almost all procedures (97%) were completed without complications. Patients with CIED-associated IE had significantly higher mortality than patients in the CIED-associated IE + PI group, and patients in the PI group had the lowest mortality. One-year, 2-year, and 5-year overall survival rates in the CIED-associated IE group were 61%, 49%, and 32%, respectively, compared with 77%, 73%, and 56% in the CIED-associated IE + PI group and 90%, 86%, and 67% in the PI group (P <0.001). Conclusions: Patients with CIED-associated IE had almost 4-fold higher 1-year mortality compared to those with PI. Patients with CIED-associated IE and PI had about 2-fold higher 1-year mortality compared to those with PI.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © by the Author(s), 2026. |
| Uncontrolled Keywords: | cardiac implantable electronic devices,cied-associated infective endocarditis,transvenous lead extraction,cardiology and cardiovascular medicine ,/dk/atira/pure/subjectarea/asjc/2700/2705 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 08 Oct 2026 10:46 |
| Last Modified: | 11 Oct 2026 05:42 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/104755 |
| DOI: | 10.33963/v.phj.111009 |
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