Carbon−Phosphorus Coupling from C^N Cyclometalated Au(III) Complexes

Bonsignore, R; Thomas, Sophie; Klooster, W T; Coles, S J; Jenkins, R L; Bourissou, D; Barone, G; Casini, A

doi:10.1002/chem.201905392

Carbon−Phosphorus Coupling from C^N Cyclometalated Au(III) Complexes

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Bonsignore, R, Thomas, Sophie ORCID: https://orcid.org/0000-0003-1110-430X, Klooster, W T, Coles, S J, Jenkins, R L, Bourissou, D, Barone, G and Casini, A (2020) Carbon−Phosphorus Coupling from C^N Cyclometalated Au(III) Complexes. Chemistry – A European Journal, 26 (19). pp. 4226-4231. ISSN 0947-6539

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Abstract

With the aim of exploiting new organometallic species for cross-coupling reactions, we report here on the Au III-mediated C aryl−P bond formation occurring upon reaction of C^N cyclometalated Au III complexes with phosphines. The [Au(C^N)Cl 2] complex 1 featuring the bidentate 2-benzoylpyridine (C CON) scaffold was found to react with PTA (1,3,5-triaza-7-phosphaadamantane) under mild conditions, including in water, to afford the corresponding phosphonium 5 through C−P reductive elimination. A mechanism is proposed for the title reaction based on in situ 31P{ 1H} NMR and HR-ESI-MS analyses combined with DFT calculations. The C−P coupling has been generalized to other C^N cyclometalated Au III complexes and other tertiary phosphines. Overall, this work provides new insights into the reactivity of cyclometalated Au III compounds and establishes initial structure–activity relationships to develop Au III-mediated C−P cross-coupling reactions.

Item Type:	Article
Uncontrolled Keywords:	carbon–phosphorous bond,cross-coupling,density functional calculations,gold(iii) cyclometalated compounds,reductive elimination,catalysis,general chemistry,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1500/1503
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	14 Sep 2026 08:21
Last Modified:	14 Sep 2026 08:26
URI:	https://ueaeprints.uea.ac.uk/id/eprint/104503
DOI:	10.1002/chem.201905392

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