Scalable low-cost interventions to support medication adherence in people prescribed treatment for hypertension in primary care: a research programme

Sutton, Stephen, Beardsell, Katja, Bhattacharya, Debi ORCID: https://orcid.org/0000-0003-3024-7453, Brimicombe, James, Cadorna, Gianna, Conceição, Raquel, De Simoni, Anna, Eborall, Helen, Griffin, Simon, Gupta, Pankaj, Hardeman, Wendy ORCID: https://orcid.org/0000-0002-6498-9407, Herbert, Kevin, Jamison, James, Mant, Jonathan, Mascolo, Cecilia, Massou, Efthalia, McManus, Richard J, Mirzaei, Venus, Morris, Stephen, Naughton, Felix ORCID: https://orcid.org/0000-0001-9790-2796, Patel, Prashanth, Prevost, Andrew Toby, Shpendi, Sonia, Takhar, Amrit, Alvarez, Catalina Trama, Van Emmenis, Miranda, de Vasconcelos, Joana Carvalho and Veic, Anamarija (2026) Scalable low-cost interventions to support medication adherence in people prescribed treatment for hypertension in primary care: a research programme. Programme Grants for Applied Research, 14 (18). pp. 1-46. ISSN 2050-4322

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Abstract

Background: About 14.9% of people (9.9 million) registered with primary care practices in England and Wales are prescribed medication for hypertension. However, many do not take their medication as prescribed. To address this problem, we need scalable interventions. Objective: To develop a scalable low-cost intervention to support medication adherence in people prescribed medication for hypertension in primary care, and to obtain precise and robust estimates of the effectiveness and cost effectiveness of the intervention compared with usual care. Design: Systematic reviews and meta-analyses; qualitative meta-synthesis; interviews and focus groups; expert consultations; pre-testing study; randomised feasibility trial; randomised controlled trial of effectiveness and cost effectiveness; economic modelling. Setting and participants: Primary care practices in England and Wales. Patients prescribed medication for hypertension with poorly controlled blood pressure. Interventions: Very brief intervention delivered by a practice nurse or healthcare assistant followed by a digital intervention (text messaging programme or smartphone app). Main outcome measures: Acceptability, feasibility, fidelity and cost of the interventions. Systolic blood pressure. Biochemical and self-reported measures of medication adherence. Results: Our systematic reviews showed that both app-based and face-to-face interventions in patients with long-term conditions have a positive effect on medication adherence.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Public Health Faculty of Medicine and Health Sciences > Research Groups > Implementation Science EAST Faculty of Medicine and Health Sciences > Research Groups > Behaviour Change EAST Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Health Promotion
Related URLs:	https://www.journalslibrary.nihr.ac.uk/p...
Depositing User:	LivePure Connector
Date Deposited:	28 Aug 2026 15:51
Last Modified:	30 Aug 2026 05:27
URI:	https://ueaeprints.uea.ac.uk/id/eprint/104393
DOI:	https://www.journalslibrary.nihr.ac.uk/pgfar/GJSS0929

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