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Van Hedent, Steven, Tatsuoka, Curtis, Carr, Sarah 
ORCID: https://orcid.org/0000-0001-6641-4415, Laukamp, Kai, Eck, Brendan, Hokamp, Nils, Kessner, Rivka, Ros, Pablo and Jordan, David
(2020)
Impact of Patient Size and Radiation Dose on Accuracy and Precision of Iodine Quantification and Virtual Noncontrast Values in Dual-layer Detector CT—A Phantom Study.
Academic Radiology.
ISSN 1076-6332
Abstract
Rationale and Objectives: Iodine quantification (IQ) and virtual noncontrast (VNC) images produced by dual-energy CT (DECT) can be used for various clinical applications. We investigate the performance of dual-layer DECT (DLDECT) in different phantom sizes and varying radiation doses and tube voltages, including a low-dose pediatric setting. Materials and Methods: Three phantom sizes (simulating a 10-year-old child, an average, and a large-sized adult) were scanned with iodine solution inserts with concentrations ranging 0-32 mg/ml, using the DLDECT. Each phantom size was scanned with CTDIvol 2-15 mGy at 120 and 140 kVp. The smallest phantom underwent additional scans with CTDIvol 0.9-1.8 mGy. All scans were repeated 3 times. Each iodine insert was analyzed using VNC and IQ images for accuracy and precision, by comparison to known values. Results: For scans from 2 to 15 mGy mean VNC attenuation and IQ error in the iodine inserts in the small, medium, and large phantoms was 1.2 HU ± 3.2, −1.2 HU ± 14.9, 2.6 HU ± 23.6; and +0.1 mg/cc ± 0.4, −0.9 mg/cc ± 0.9, and −1.8 mg/cc ± 1.8, respectively. In this dose range, there were no significant differences (p ≥ 0.05) in mean VNC attenuation or IQ accuracy in each phantom size, while IQ was significantly less precise in the small phantom at 2 mGy and 10 mGy (p < 0.05). Scans with CTDIvol 0.9-1.8 mGy in the small phantom showed a limited, but statistically significantly lower VNC attenuation precision and IQ accuracy (−0.5 HU ± 5.3 and −0.3 mg/cc ± 0.5, respectively) compared to higher dose scans in the same phantom size. Conclusion: Performance of iodine quantification and subtraction by VNC images in DLDECT is largely dose independent, with the primary factor being patient size. Low-dose pediatric scan protocols have a significant, but limited impact on IQ and VNC attenuation values.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Social Sciences > School of Psychology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 19 Aug 2026 14:45 |
| Last Modified: | 19 Aug 2026 14:45 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/104246 |
| DOI: | 10.1016/j.acra.2019.02.013 |
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