Tools
Tools
MACDONALD, Alexander S., MCCONNACHIE, Alex, DICKIE, David Alexander, BATH, Philip M., FORBES, Kirsten, QUINN, Terence, BROOMFIELD, Niall M. 
ORCID: https://orcid.org/0000-0003-2599-3435, DANI, Krishna, DONEY, Alex, MUIR, Keith W., STRUTHERS, Allan, WALTERS, Matthew, BARBER, Mark, BHALLA, Ajay, CAMERON, Alan, GUYLER, Paul, HASSAN, Ahamad, KEARNEY, Mark, KEEGAN, Breffni, LAKSHMANAN, Sekaran, MACLEOD, Mary Joan, RANDALL, Marc, SHAW, Louise, SUBRAMANIAN, Ganesh, WERRING, David and DAWSON, Jesse
(2024)
Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST.
Journal of Human Hypertension, 38 (4).
pp. 307-313.
ISSN 0950-9240
Preview |
PDF (s41371-024-00906-5)
- Published Version
Available under License Creative Commons Attribution. Download (716kB) | Preview |
Abstract
Blood Pressure Variability (BPV) is associated with cardiovascular risk and serum uric acid level. We investigated whether BPV was lowered by allopurinol and whether it was related to neuroimaging markers of cerebral small vessel disease (CSVD) and cognition. We used data from a randomised, double-blind, placebo-controlled trial of two years allopurinol treatment after recent ischemic stroke or transient ischemic attack. Visit-to-visit BPV was assessed using brachial blood pressure (BP) recordings. Short-term BPV was assessed using ambulatory BP monitoring (ABPM) performed at 4 weeks and 2 years. Brain MRI was performed at baseline and 2 years. BPV measures were compared between the allopurinol and placebo groups, and with CSVD and cognition. 409 participants (205 allopurinol; 204 placebo) were included in the visit-to-visit BPV analyses. There were no significant differences found between placebo and allopurinol groups for any measure of visit-to-visit BPV. 196 participants were included in analyses of short-term BPV at week 4. Two measures were reduced by allopurinol: the standard deviation (SD) of systolic BP (by 1.30 mmHg (95% confidence interval (CI) 0.18–2.42, p = 0.023)); and the average real variability (ARV) of systolic BP (by 1.31 mmHg (95% CI 0.31–2.32, p = 0.011)). There were no differences in other measures at week 4 or in any measure at 2 years, and BPV was not associated with CSVD or cognition. Allopurinol treatment did not affect visit-to-visit BPV in people with recent ischemic stroke or TIA. Two BPV measures were reduced at week 4 by allopurinol but not at 2 years.
| Item Type: | Article |
|---|---|
| Additional Information: | Data availability: The datasets analysed that support the findings of the present study are available from the corresponding author upon reasonable request. |
| Uncontrolled Keywords: | internal medicine ,/dk/atira/pure/subjectarea/asjc/2700/2724 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Mental Health and Social Care (fka Lifespan Health) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 14 Aug 2026 14:54 |
| Last Modified: | 19 Aug 2026 15:16 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/104153 |
| DOI: | 10.1038/s41371-024-00906-5 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |