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Hassard, Francis, Curtis, Thomas P., Dotro, Gabriela C., Golyshin, Peter, Gutierrez, Tony, Heaven, Sonia, Horsfall, Louise, Jefferson, Bruce, Jones, Davey L., Krasnogor, Natalio, Kumar, Vinod, Lea-Smith, David J. 
ORCID: https://orcid.org/0000-0003-2463-406X, Le Corre Pidou, Kristell, Liu, Yongqiang, Lyu, Tao, McCarthy, Ronan R., McKew, Boyd, Smith, Cindy, Yakunin, Alexander, Yang, Zhugen, Zhang, Yue and Coulon, Frederic
(2024)
Scaling-up Engineering Biology for Enhanced Environmental Solutions.
ACS Synthetic Biology, 13 (6).
pp. 1586-1588.
ISSN 2161-5063
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Abstract
Synthetic biology (SynBio) offers transformative solutions for addressing environmental challenges by engineering organisms capable of degrading pollutants, enhancing carbon sequestration, and valorizing waste (Figure 1). These innovations hold the potential to revolutionize bioremediation strategies, ecosystem restoration, and sustainable environmental management. (1) Advances in SynBio, including automation, precise manipulation of genetic material, (2) and design of semisynthetic organisms with enhanced capabilities, can improve the efficiency of microbes for eliminating pollutants such as hydrocarbons and plastics or extracting valuable resources from the environment. (3) Genome editing technologies, such as CRISPR-Cas9, allows the editing of genomes with unprecedented accuracy, facilitating the development of organisms with desired traits or functions. (4) Furthermore, SynBio encompasses the engineering of metabolic enzymes within organisms, leading to the design of microbial factories capable of degrading complex and persistent chemicals, and converting waste to valuable resources. (5) These advancements also facilitate the manipulation of bacterial social behaviors, offering the capacity for tunable control at the multicellular level and engineered biofilms. (5)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | biomedical engineering,biochemistry, genetics and molecular biology (miscellaneous) ,/dk/atira/pure/subjectarea/asjc/2200/2204 |
| Faculty \ School: | Faculty of Science > School of Computing Sciences Faculty of Science > School of Biological Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 14 Aug 2026 12:43 |
| Last Modified: | 14 Aug 2026 12:43 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/104142 |
| DOI: | 10.1021/acssynbio.4c00292 |
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