DynDom1D_Python: An Open-Source Python tool for the analysis of domain movements in proteins

Lim, Jien, Millard, Hugh and Hayward, Steven ORCID: https://orcid.org/0000-0001-6959-2604 (2026) DynDom1D_Python: An Open-Source Python tool for the analysis of domain movements in proteins. Journal of Open Source Software, 11 (124). pp. 1-5. ISSN 2475-9066

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Abstract

Here we introduce DynDom1D_Python, an open-source Python implementation based on the original DynDom Fortran program for the analysis of domain movements in proteins. DynDom works on a single protein chain and can be used when two structures of the same protein are available representing a conformational change. If appropriate, it describes the conformational change in terms of the relative rotation of quasi-rigid regions called "dynamic domains" by way of hinge axes (more precisely, interdomain screw axes) and hinge-bending residues (more precisely, interdomain bending residues). This new implementation improves on the original standalone version in a number of ways.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Computing Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Computational Biology
Depositing User:	LivePure Connector
Date Deposited:	14 Aug 2026 10:10
Last Modified:	14 Aug 2026 10:10
URI:	https://ueaeprints.uea.ac.uk/id/eprint/104133
DOI:	10.21105/joss.09938

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