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Fu, Hui-Hui, Wang, Ming-Chen, Wang, Zhi-Qing, Sang, Yu-Han, Li, Zhen-Kun, Li, Fei-Fei, Liu, Jia-Rong, Qin, Qi-Long, Zhu, Xiao-Yu, Wang, Na, Wan, Jin-Jian, Teng, Zhao-Jie, Zhang, Wei-Peng, Gates, Andrew J. 
ORCID: https://orcid.org/0000-0002-4594-5038, Li, Chun-Yang, Todd, Jonathan D. and Zhang, Yu-Zhong
(2026)
Regulation of DMSP organosulfur cycling in ubiquitous Roseobacter marine bacteria.
EMBO Journal, 45 (6).
pp. 1980-1996.
ISSN 0261-4189
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Abstract
Dimethylsulfoniopropionate (DMSP) catabolism by marine Roseobacters is important for global biogeochemical cycling and the climate. Many Roseobacters contain competing DMSP demethylation and cleavage pathways, but only cleavage produces the climate-cooling gas dimethylsulfide. Here, we identify the “switch” regulator in Roseobacters, DmdR, which transcriptionally represses demethylation (dmdA, encoding DMSP demethylase), cleavage (acuI, encoding acryloyl-CoA reductase) and oxidative stress protection (dmdEF, dinB) genes under low intracellular DMSP levels. Increased DMSP levels lead to DMSP cleavage and accumulation of cytotoxic cleavage product acryloyl-CoA. Acryloyl-CoA binding to DmdR derepresses dmdA-acuI transcription to stimulate acryloyl-CoA catabolism and DMSP demethylation. Upregulation of the newly identified peroxidase DmdF, and possibly also of DmdE and DinB, counteracts oxidative stress associated with DMSP demethylation. Thus, DmdR, along with DmdR-independent regulators of DMSP cleavage, likely maintains cellular DMSP levels to allow its antistress functions, but accelerates demethylation and catabolism of toxic intermediates at higher DMSP levels. Of note, DmdR appears to control acryloyl-CoA catabolism/detoxification even in abundant marine bacteria lacking dmdA, suggesting additional mechanisms. DmdR and DmdEF are widespread in Earth’s oceans and important for biogeochemical cycling and climate-active gas production.
| Item Type: | Article |
|---|---|
| Additional Information: | Data availability: This study includes no data deposited in external repositories. The source data of this paper are collected in the following database record: biostudies:S-SCDT-10_1038-S44318-026-00706-2. |
| Uncontrolled Keywords: | coordinated regulation,dmsp catabolism,marine bacteria,transcriptional regulator,general neuroscience,molecular biology,general biochemistry,genetics and molecular biology,general immunology and microbiology,sdg 13 - climate action,sdg 14 - life below water ,/dk/atira/pure/subjectarea/asjc/2800/2800 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Groups > Wolfson Centre for Advanced Environmental Microbiology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Aug 2026 15:16 |
| Last Modified: | 10 Aug 2026 00:02 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/104001 |
| DOI: | 10.1038/s44318-026-00706-2 |
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