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Guo, Yang, Wang, Zongan, Li, Denghui, Wang, Lele, Lan, Hongxia, Guo, Fei, Zhao, Ziyu, Liu, Zhenjun, Meng, Liang, Shen, Xuechun, Wang, Minxiao, Zhao, Weishu, Zhang, Weijia, Kong, Chaodi, Shi, Liuxin, Sun, Ying, Seim, Inge, Jiang, Aijun, Ma, Kailong, Su, Zidong, Zhang, Nannan, Ji, Qianyue, Chen, Junyi, Chen, Ke, Qi, Chen, Li, Baitao, He, Beibei, Liu, Yuqian, Zhou, Jiayong, Zheng, Yue, Zhang, Huan, Wang, Yinzhao, Han, Mo, Yang, Tao, Tong, Jiawei, Zhang, Yulu, Wang, Zhijie, Xu, Xiaokai, Chen, Jiayu, Liu, Yue, Chen, Haixin, Zeng, Tao, Wei, Xiaofeng, Li, Chaolun, Yang, Huanming, Wang, Bo, Liu, Xin, Shao, Changwei, Zhang, Wenwei, Gu, Ying, Xiao, Xiang, Xu, Xun, Wang, Jian, Mock, Thomas 
ORCID: https://orcid.org/0000-0001-9604-0362, Fan, Guangyi, Li, Yuxiang, Liu, Shanshan and Dong, Yuliang
(2026)
The genetic repertoire of deep-sea microbiome: From sequence to structure and function.
Cell Host and Microbe.
ISSN 1931-3128
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Abstract
The deep sea, as the largest and maybe most hostile environment on Earth, is still underexplored, especially regarding its genetic repertoire. Yet, previous work has revealed significant habitat-specific deep-sea biodiversity. Here, we present an integrated deep-sea microbial genetic dataset comprising 502 million nonredundant genes from 2,138 samples and 2.4 million predicted structures and use it to link specific protein structures with genetic variants associated with life in the deep sea and to assess their biotechnology potential. Combining global sequence analysis with biophysical and biochemical measurements revealed unprecedented sequence diversity and substantial structural conservation of proteins. Especially, proteins involved in replication, recombination, and repair were identified as being under rapid evolution and with specialized properties. Among these, a structurally divergent helicase exhibited advantages in controlling nanopore sequencing speed. Thus, our work positions the deep sea as an evolutionary engine that generates and hosts genetic diversity and bridges genetic knowledge with biotechnology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ai-driven structural prediction,deep sea,evolution,gene catalog,genome editing,helicase,marine metagenome,microbial dark matter,protein mining,protein structure,parasitology,microbiology,virology,sdg 14 - life below water ,/dk/atira/pure/subjectarea/asjc/2400/2405 |
| Faculty \ School: | University of East Anglia Research Groups/Centres > Theme - ClimateUEA Faculty of Science > School of Environmental Sciences |
| UEA Research Groups: | Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation Faculty of Science > Research Groups > Wolfson Centre for Advanced Environmental Microbiology Faculty of Science > Research Groups > Environmental Biology Faculty of Science > Research Groups > Centre for Ocean and Atmospheric Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 15 Jul 2026 15:29 |
| Last Modified: | 15 Jul 2026 15:29 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/103864 |
| DOI: | 10.1016/j.chom.2026.05.009 |
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