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Valverde, Guido, Sarhan, Mohamed S., Cook, Ryan, Rota-Stabelli, Omar, Adriaenssens, Evelien M. 
ORCID: https://orcid.org/0000-0003-4826-5406, Zink, Albert and Maixner, Frank
(2026)
An ancient genome of Streptococcus pyogenes from a pre-Columbian Bolivian mummy.
Nature Communications, 17 (1).
ISSN 2041-1723
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Abstract
Streptococcus pyogenes, or Group A Streptococcus (GAS), is a human pathogen responsible for a range of diseases, from mild infections to severe illnesses. Despite its significance in modern clinical settings, little is known about the pathogen’s evolutionary history or its presence in ancient human populations. Here, we present genomic evidence of S. pyogenes in the pre-Columbian Americas. We analysed a tooth from a naturally mummified individual dating to the Late Intermediate Period (1283–1383 cal AD), housed in the National Museum of Archeology (MUNARQ) in La Paz, Bolivia. Mitochondrial DNA analysis confirmed the host’s Native American ancestry. Shotgun metagenomic sequencing and de-novo assembly enabled the near-complete reconstruction of an ancient S. pyogenes genome displaying close similarity to contemporary strains linked to pharyngitis. The genome contains core virulence genes, but prophages lack streptococcal pyrogenic exotoxins. Phylogenetic analyses place the strain at the base of modern S. pyogenes diversity, and Bayesian analyses indicate that most extant lineages diversified globally within the past ~5,500 years. Our results push back the confirmed presence of S. pyogenes in the Americas by several centuries and suggest that the pathogen circulated among Indigenous populations prior to the European contact.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 09 Jul 2026 11:50 |
| Last Modified: | 13 Jul 2026 23:02 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/103805 |
| DOI: |
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