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Cameron, Donnie 
ORCID: https://orcid.org/0000-0001-9841-6909, Clark, Allan ORCID: https://orcid.org/0000-0003-2965-8941, Vermeulen, Laura J., Malekzadeh, Arjan, Vassiliou, Vassilios S. ORCID: https://orcid.org/0000-0002-4005-7752 and Hooijmans, Melissa T.
(2026)
A systematic review and meta-analysis of the effects of older age on skeletal muscle mitochondrial function, as measured by 31P magnetic resonance.
UNSPECIFIED.
Abstract
Objective: Loss of skeletal muscle mass and performance is a hallmark of ageing. Mitochondrial function has been suggested as a critical determinant of skeletal muscle performance. However, mixed results have been reported regarding mitochondrial function in older individuals. Therefore, the primary objective of this systematic review is to determine whether 31P-MRS-derived τPCr, reflecting mitochondrial oxidative capacity, is reduced in ageing skeletal muscle. Methods: A preregistered systematic literature review was performed using the databases MEDLINE, EMBASE, SPORTDiscus, and Cochrane Central Register of Controlled Trials (CENTRAL). Papers were included if they reported τPCr as measured by 31P-MRS; and studied individuals over 65 years of age in combination with a younger control group. Differences between young and older groups were assessed using random effects meta-analysis. Results: We included 20 papers in total, of which 2 measured 2 muscles, 5 focused on the tibialis anterior (TA) muscle, 11 on the calf muscles, 5 on the quadriceps, and 1 on the flexor digitorum longus. No statistically-significant differences were found in τPCr between older and younger adults for all muscles combined (Hedges’ g=0.11 (p=0.487). Inter-study heterogeneity was high (τ2=0.36, I2=72.49%, H2=3.64). Sub-analyses for the individual muscles showed longer τPCr in the quadriceps (g=0.65, p<0.001) in older adults, but shorter τPCr in the TA muscle (g=−0.64, p<0.001). For the calf muscles, no differences were detected between older and young individuals (g=0.20, p=0.377). Conclusion: No uniform age-related decline was found for τPCr when comparing all studies together. Substantial heterogeneity was observed between the individual muscles, with τPCr being prolonged in the upper leg muscles in older adults, but shortened in the tibialis anterior. This suggests more work using standardised settings and well-defined cohorts is needed.
| Item Type: | Other |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Public Health Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Science > Research Groups > Statistics Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Jul 2026 08:37 |
| Last Modified: | 02 Jul 2026 08:37 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/103594 |
| DOI: | 10.64898/2026.05.02.722217 |
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