HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry

The UK-PSC Consortium (2017) HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry. HLA, 90 (4). pp. 228-233. ISSN 2059-2302

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Abstract

Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the causative HLA alleles. When assessing haplotypes carrying HLA-DRB1*13:01 (hypothesized to specifically increase the susceptibility to chronic cholangitis), we observed that every haplotype in the Scandinavian PSC population carried HLA-DQB1*06:03. In contrast, only 65% of HLA-DRB1*13:01 haplotypes in an admixed/non-European PSC population carried this allele, suggesting that further assessments of the PSC-associated haplotype HLA-DRB1*13:01-DQA1*01:03-DQB1*06:03 in admixed or multi-ethnic populations could aid in identifying the causative allele.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Uncontrolled Keywords:	causative,human leukocyte antigen,multi-ethnic,psc,trans-ancestry,immunology and allergy,immunology,genetics ,/dk/atira/pure/subjectarea/asjc/2700/2723
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	30 Jun 2026 13:55
Last Modified:	08 Jul 2026 13:48
URI:	https://ueaeprints.uea.ac.uk/id/eprint/103560
DOI:	10.1111/tan.13076

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