Lansoprazole-induced acute lung and liver injury:A case report

Atkins, Christopher, Maheswaran, Tina, Rushbrook, Simon and Kamath, Ajay (2014) Lansoprazole-induced acute lung and liver injury:A case report. International Journal of Clinical Pharmacology and Therapeutics, 52 (12). pp. 1102-1104. ISSN 0946-1965

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Abstract

A 61-year old woman was admitted with increasing dyspnea and deranged liver function tests. A chest X-ray revealed small volume lungs with reticulo-nodular shadowing. High resolution computed tomography of the chest revealed interlobular septal thickening. The patient subsequently underwent an open lung biopsy and ultrasound-guided liver biopsy, which were consistent with a hypersensitivity pneumonitis and drug-induced liver injury respectively. The patient had previously been commenced on lansoprazole 10 days before the onset of symptoms; this had been stopped at diagnosis. High dose prednisolone was commenced, and the patient went on to make a full recovery. Hypersensitivity pneumonitis is a form of interstitial lung disease that is rarely associated with lansoprazole; this is the first report of it causing an idiosyncratic reaction affecting the lung and liver simultaneously. This case demonstrates the importance of obtaining a full drug history, as early identification of the offending agent will improve outcomes.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2014 Dustri-Verlag Dr. K. Feistle.
Uncontrolled Keywords:	acute liver injury,acute lung injury,adverse reaction,lansoprazole,pharmacology,pharmacology (medical) ,/dk/atira/pure/subjectarea/asjc/3000/3004
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	30 Jun 2026 13:47
Last Modified:	30 Jun 2026 13:47
URI:	https://ueaeprints.uea.ac.uk/id/eprint/103555
DOI:	10.5414/CP202110

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