T-regulatory lymphocytes and chronic viral hepatitis

Rushbrook, Simon M., Hoare, Matthew and Alexander, Graeme J.M. (2007) T-regulatory lymphocytes and chronic viral hepatitis. Expert Opinion on Biological Therapy, 7 (11). pp. 1689-1703. ISSN 1471-2598

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Abstract

Both hepatitis B virus (HBV) and hepatitis C virus (HCV) can cause persistent viral infection in humans. Chronic infection is associated with a risk of cirrhosis and hepatocellular carcinoma. The cause of chronic infection is unknown. A large body of evidence suggests that a failure of the adaptive immune response is critical in the establishment of chronic infection. Recently a new group of T cells (T-regulatory cells), that express CD4 +CD25+ and Foxp3, which can inhibit the cellular (CD4 +/CD8+) immune response have been described. In this review the authors explore the thoughts regarding immune responses to HBV and HCV infections and the role of these T-regulatory cells in relation to the pathogenesis of chronic HBV and HCV infection and the potential for therapeutic intervention.

Item Type:	Article
Uncontrolled Keywords:	foxp3,hepatitis b,hepatitis c,regulatory t cells,viral hepatitis,pharmacology,drug discovery,clinical biochemistry ,/dk/atira/pure/subjectarea/asjc/3000/3004
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	30 Jun 2026 13:25
Last Modified:	30 Jun 2026 13:25
URI:	https://ueaeprints.uea.ac.uk/id/eprint/103536
DOI:	10.1517/14712598.7.11.1689

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