Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR:Consequences for HIV infection and immunity

Soilleux, Elizabeth J., Morris, Lesley S., Rushbrook, Simon, Lee, Benhur and Coleman, Nicholas (2002) Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR:Consequences for HIV infection and immunity. Human Pathology, 33 (6). pp. 652-659. ISSN 0046-8177

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Abstract

DC-SIGNR is a human immunodeficiency virus (HIV-binding C-type lectin that is expressed on endothelium in the hepatic sinusoids, lymph node sinuses and placenta. Like closely related DC-SIGN, DC-SIGNR can bind both ICAM-3 and HIV and can potentiate HIV infection of T lymphocytes in trans. In the present study we have investigated reasons underlying the restricted distribution of DC-SIGNR and have examined DC-SIGNR expression in relation to HIV entry receptors. We show that DC-SIGNR expression does not depend on endothelial cell specialization or on activation state. DC- SIGNR-positive endothelium continues to express DC-SIGNR in conditions of hyperplasia, whereas the molecule is lost after neoplastic transformation, most likely as a result of changes in the microenvironment of the endothelial cells. We have further shown that CCR5, but not CD4, is coexpressed with DC-SIGNR on hepatic sinusoidal and placental capillary endothelial cells. However, CD4-positive CCR5-positive cells, such as hepatic Kupffer cells, placental Hofbauer cells, and CD4-positive T lymphocytes in lymph nodes, can be found adjacent to DC-SIGNR-positive endothelium. Therefore, DC-SIGNR may be able to mediate HIV infection of these cells in trans. Finally, we demonstrate that DC-SIGN and DC-SIGNR can be coexpressed on lymph node sinus endothelial cells, which may lead to modulation of the function of both molecules.

Item Type:	Article
Uncontrolled Keywords:	dc-sign,dc-signr,endothelium,human inmmnodeficiency virus,liver,pathology and forensic medicine ,/dk/atira/pure/subjectarea/asjc/2700/2734
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	30 Jun 2026 12:33
Last Modified:	01 Jul 2026 07:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/103523
DOI:	10.1053/hupa.2002.124036

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