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ToolsHou, Mingzhu, Bergamino, Maurizio, de Chastelaine, Marianne, Sambamoorthy, Sowmya and Rugg, Michael D. (2024) Free water-corrected fractional anisotropy of the fornix and parahippocampal cingulum predicts longitudinal memory change in cognitively healthy older adults. Neurobiology of Aging, 142. pp. 17-26. ISSN 0197-4580
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Abstract
Prior studies have reported inconsistent results regarding the relationships between the integrity of the fornix and parahippocampal cingulum and both memory performance and longitudinal change in performance. In the present study, we examined associations in a sample of cognitively healthy older adults between free water-corrected fractional anisotropy (FA) metrics derived from the fornix and cingulum, baseline memory performance, and 3-year memory change. Neither fornix nor cingulum FA correlated with memory performance at baseline. By contrast, FA of each tract was predictive of memory change, such that greater FA was associated with less longitudinal decline. These associations remained significant after controlling for FA of other white matter tracts and for performance in other cognitive domains. Furthermore, fornix and cingulum FA explained unique variance in memory change. These results suggest that free water-corrected measures of fornix and parahippocampal cingulum integrity are reliable predictors of future memory change in cognitively healthy older adults. The findings for the fornix in particular highlight the utility of correcting for free water when estimating diffusion tensor imaging metrics of white matter integrity.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2024 Elsevier Inc. |
| Uncontrolled Keywords: | aging,cognitive change,cognitive performance,diffusion tensor imaging,hippocampus,structural connectivity,general neuroscience,ageing,clinical neurology,developmental biology,geriatrics and gerontology ,/dk/atira/pure/subjectarea/asjc/2800/2800 |
| Faculty \ School: | Faculty of Social Sciences > School of Psychology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 22 Jun 2026 15:56 |
| Last Modified: | 23 Jun 2026 07:56 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/103470 |
| DOI: | 10.1016/j.neurobiolaging.2024.04.005 |
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