Patterns of retrieval-related cortico-striatal connectivity are stable across the adult lifespan

Hill, Paul F., de Chastelaine, Marianne and Rugg, Michael D. (2023) Patterns of retrieval-related cortico-striatal connectivity are stable across the adult lifespan. Cerebral Cortex, 33 (8). pp. 4542-4552. ISSN 1047-3211

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Abstract

Memory retrieval effects in the striatum are well documented and robust across experimental paradigms. However, the functional significance of these effects, and whether they are moderated by age, remains unclear. We used functional magnetic resonance imaging paired with an associative recognition task to examine retrieval effects in the striatum in a sample of healthy young, middle-aged, and older adults. We identified anatomically segregated patterns of enhanced striatal blood oxygen level-dependent (BOLD) activity during recollection- and familiarity-based memory judgments. Successful recollection was associated with enhanced BOLD activity in bilateral putamen and nucleus accumbens, and neither of these effects were reliably moderated by age. Familiarity effects were evident in the head of the caudate nucleus bilaterally, and these effects were attenuated in middle-aged and older adults. Using psychophysiological interaction analyses, we observed a monitoring-related increase in functional connectivity between the caudate and regions of the frontoparietal control network, and between the putamen and bilateral retrosplenial cortex and intraparietal sulcus. In all instances, monitoring-related increases in cortico-striatal connectivity were unmoderated by age. These results suggest that the striatum, and the caudate in particular, couples with the frontoparietal control network to support top-down retrieval-monitoring operations, and that the strength of these inter-regional interactions is preserved in later life.

Item Type:	Article
Additional Information:	Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press. All rights reserved.
Uncontrolled Keywords:	cognitive aging,episodic memory,frontoparietal control network,functional connectivity,post-retrieval monitoring,striatum,cognitive neuroscience,cellular and molecular neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2805
Faculty \ School:	Faculty of Social Sciences > School of Psychology
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	19 Jun 2026 16:00
Last Modified:	19 Jun 2026 16:00
URI:	https://ueaeprints.uea.ac.uk/id/eprint/103456
DOI:	10.1093/cercor/bhac360

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