Is There Evidence of Diagnostic and Treatment Gaps for LUTS in Post-Menopausal Women With Genitourinary Syndrome of the Menopause? ICI-RS 2025

Apostolidis, Apostolos, Da Silva, Ana Sofia, Gray, Thomas, Khullar, Vik, Mohamed-Ahmed, Rayan, Papaefstathiou, Efstathios, Van den Ende, Mauro, Wein, Alan, Abrams, Paul and Robinson, Dudley (2025) Is There Evidence of Diagnostic and Treatment Gaps for LUTS in Post-Menopausal Women With Genitourinary Syndrome of the Menopause? ICI-RS 2025. Neurourology and Urodynamics. ISSN 0733-2467

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Abstract

Aims: This report, from the International Consultation on Incontinence-Research Society, aims to evaluate the existing evidence and identify diagnostic and treatment gaps for Lower Urinary Tract Symptoms (LUTS) in post-menopausal women with Genitourinary Syndrome of Menopause (GSM).  Methods: An overview on the current literature, including pathophysiology, diagnosis and management of GSM associated LUTS, including incontinence, overactive bladder, underactive bladder and recurrent urinary tract infections (rUTIs).  Results: Significant gaps in the literature were identified. GSM is underdiagnosed and the interplay between hormonal changes in the postmenopausal period on LUTS remains poorly understood. Diagnostic methods for rUTIs lack sensitivity and the role of the urinary microbiome is emerging. Current treatments, including topical oestrogens and systemic hormone therapy, lack long-term efficacy data on LUTS. Evidence for regenerative medicine techniques remain limited by low-quality studies and short-term follow up.  Conclusion: There is lack of high-quality evidence, which hinders the optimal management of LUTS in post-menopausal women with GSM. The panel proposes targeted research questions, focusing on the hormonal impact on the lower urinary tract, advancing diagnostics and robust clinical trials for existing and novel therapies, to bridge current gaps in the literature and improve patient care.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2025 Wiley Periodicals LLC.
Uncontrolled Keywords:	clinical neurology,urology ,/dk/atira/pure/subjectarea/asjc/2700/2728
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	05 Jun 2026 14:48
Last Modified:	05 Jun 2026 14:48
URI:	https://ueaeprints.uea.ac.uk/id/eprint/103303
DOI:	10.1002/nau.70173

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