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ToolsZheng, Li-Yuan, Jiang, Wen-Xin, Sun, Xiao-Meng, Liu, Li, Teng, Zhao-Jie, Wang, Hou-Qi, Zhu, Wen-Jing, Ge, Chang, Qin, Qi-Long, Liu, Ning-Hua, Cao, Hai-Yan, Fu, Hui-Hui, Li, Chun-Yang, Todd, Jonathan, Chen, Xiu-Lan, Zhang, Yu-Zhong and Wang, Peng (2026) Metabolic Regulation of Dimethylsulfoniopropionate Cleavage and Dimethyl Sulfide Production in Halomonas sp. D47. Advanced Science, 13 (23). ISSN 2198-3844
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Abstract
Dimethylsulfoniopropionate (DMSP) is a globally significant marine organosulfur compound with diverse ecological roles, including environmental stress protection, chemotaxis, and nutrient cycling. Its microbial catabolism is crucial for the marine sulfur cycle, generating dimethyl sulfide (DMS), a volatile gas that influences global sulfur fluxes, cloud formation, and climate regulation. Despite its importance, the metabolic regulatory mechanisms governing bacterial DMSP cleavage and DMS production remain unclear. Here, using the model DMSP-catabolizing bacterium Halomonas sp. D47, a complex regulatory mechanism involving two transcriptional regulators, AcuR and AcuZ, was elucidated through integrated genetic and biochemical analyses, in which they coordinate the orderly progression of DMSP catabolism. These regulators sense external signals from DMSP and its metabolites, fine-tuning gene expression to balance metabolism and detoxification, thereby maintaining cellular integrity. Bioinformatics analyses suggest that this regulatory scheme is conserved among certain efficient DMSP-metabolizing bacteria. Our findings provide key insights into the regulation of DMSP catabolism and highlight a potentially bacterial strategy for balancing metabolic demands with cellular homeostasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | anti-greenhouse gas,dimethyl sulfide,dimethylsulfoniopropionate,sulfur cycle,transcriptional regulation,medicine (miscellaneous),general chemical engineering,biochemistry, genetics and molecular biology (miscellaneous),general materials science,general engineering,general physics and astronomy,sdg 13 - climate action,sdg 14 - life below water ,/dk/atira/pure/subjectarea/asjc/2700/2701 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Wolfson Centre for Advanced Environmental Microbiology Faculty of Science > Research Groups > Molecular Microbiology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Jun 2026 14:31 |
| Last Modified: | 12 Jun 2026 07:38 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/103302 |
| DOI: | 10.1002/advs.202514858 |
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