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ToolsPipingas, Andrew, Reddan, Jeffery Michael, Gauci, Sarah, Young, Lauren M., Kennedy, Greg, Rowsell, Renee, King, Rebecca, Spiteri, Sam, Minihane, Anne Marie and Scholey, Andrew (2023) Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study. Nutrients, 15 (9). ISSN 2072-6643
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Abstract
The use of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplements is increasingly common among middle-aged and older adults. Users of ω-3 PUFA supplements often report using such supplements to support cognitive health, despite mixed findings reported within the ω-3 PUFA literature. To date, very few studies have explored cognitive effects in distinctly middle-aged (40 to 60 years) adults, and none have examined the acute effects (in the hours following a single dose) on cognitive performance. The current study evaluated whether a single dose of ω-3 PUFA (4020 mg docosahexaenoic acid and 720 mg eicosapentaenoic acid) influences cognitive performance and cardiovascular function in middle-aged males. Cognitive performance and cardiovascular function were assessed before and 3.5–4 h after consumption of a high dose of ω-3 PUFA (DHA + EPA) or placebo, incorporated into a standardized meal (i.e., single serve of Greek yogurt). In this study of middle-aged males, no significant differential treatment effects were observed for cognitive performance. However, a significant reduction in aortic systolic blood pressure (pre-dose to post-dose) was apparent following consumption of the ω-3 PUFA (DHA + EPA) treatment (mean difference = −4.11 mmHg, p = 0.004) but not placebo (mean difference = −1.39 mmHg, p = 0.122). Future replication in a sample comprising females, as well as patients with hypertension, is merited.
| Item Type: | Article |
|---|---|
| Additional Information: | The data presented in this study is not publicly available due to privacy and ethical restrictions. Requests for data by suitably qualified individuals may be sent to the corresponding author. |
| Uncontrolled Keywords: | acute,blood pressure,cognition,dha,middle-aged,nootropic,omega-3 pufa,food science,nutrition and dietetics ,/dk/atira/pure/subjectarea/asjc/1100/1106 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 28 May 2026 16:13 |
| Last Modified: | 31 May 2026 05:28 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/103200 |
| DOI: | 10.3390/nu15092198 |
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