DNA supercoiling and transcription: topological coupling of promoters

Lilley, David M. J., Chen, Dongrong and Bowater, Richard P. (1996) DNA supercoiling and transcription: topological coupling of promoters. Quarterly Reviews of Biophysics, 29 (3). pp. 203-225. ISSN 0033-5835

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Abstract

DNA supercoiling is a consequence of the double-stranded nature of DNA. When a linear DNA molecule is ligated into a covalently closed circle, the two strands become intertwined like the links of a chain, and will remain so unless one of the strands is broken. The number of times one strand is linked with the other is described by a fundamental property of DNA supercoiling, the linking number (Lk).

Item Type:	Article
Uncontrolled Keywords:	biophysics ,/dk/atira/pure/subjectarea/asjc/1300/1304
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	27 May 2026 11:09
Last Modified:	27 May 2026 11:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/103171
DOI:	10.1017/s0033583500005825

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